The State Key Laboratory of Tibetan Plateau Earth System, Environment and Resources (TPESER) conducts research on the processes and mechanisms of multi-sphere coupling on the Tibetan Plateau, forms platforms of academic leadership, observation and testing, international cooperation and talent convergence, and provides an innovative paradigm of integrated Earth system science research. By undertaking major missions, it brings together relevant teams and international talents to address problems of frontiers of basic science and key technologies. TPESER strives to become a leader in Earth system science and aims to build itself into an international open research hub with “leading platforms”.